World Triathlon

Major modifications for 2025:

PROHIBITED SUBSTANCES

S0. Non-Approved Substances
• S-107 and S48168 (ARM210) were added to S0 as examples of the class of ryanodine
receptor-1-calstabin complex stabilizers. The ryanodine receptor-1-calstabin complex is
a major component of calcium storage and release, serving to maintain skeletal muscle
function.

S3. Beta-2 Agonists
• Based on a recent publication on potential performance-enhancing doses of inhaled
formoterol, the dosing intervals were updated to ensure that ergogenic effects are not
achieved. These new 12-hourly dosing intervals are consistent with manufacturers’
recommended use; the maximum delivered dose is unchanged at 54 micrograms over
24 hours.

S5. Diuretics and Masking Agents
• Xipamide was added as an example of a diuretic.

S4. Hormone and Metabolic Modulators
• Elacestrant was added as an example of an anti-estrogen.
• Mitochondrial open reading frame of the 12S rRNA-c (MOTS-c) was added as an
example of an AMP-activated protein kinase activator.
• For clarity, S519 and S597 were added as examples of insulin-mimetics.
Insulinmimetics compounds or selective insulin receptor modulators (SIRMs) mimic insulin action by binding to the insulin receptor.

PROHIBITED METHODS

M1. Manipulation of Blood and Blood Components
• Donation of blood or blood components (e.g. plasma, red blood cells, white blood cells, platelets and peripheral blood stem cells)
including by apheresis is not prohibited when performed in a collection center accredited by the relevant regulatory authority of the country in which it operates.

M3. Gene and Cell Doping
• Minor editorial change was made for clarity.

Furthermore, the following substances are placed on the 2025 Monitoring Program:

1. Anabolic Agents:
In and Out-of-Competition: Ecdysterone

2. Peptides Hormones, Growth Factors, Related Substances, and Mimetics:
In and Out-of-Competition: Gonadotrophin-releasing hormone (GnRH) analogues in females under 18 years only.

3. Hypoxen (polyhydroxyphenylene thiosulfonate sodium):
In and Out-of-Competition

4. Stimulants:
In-Competition only: Bupropion, caffeine, nicotine, phenylephrine,
phenylpropanolamine, pipradrol and synephrine.

5. Narcotics:
In-Competition only: Codeine, dermorphin (and its analogues), dihydrocodeine,
hydrocodone and tapentadol
Out-of-Competition: Fentanyl and tramadol

6. Semaglutide:
In and Out-of-Competition